jump to example.com
newsletter linked in

Study: Dying cells essential to muscle development and repair

uva-logoDying cells play an unexpected and vital role in the creation of muscle fibers, researchers at the University of Virginia School of Medicine have determined. The finding could lead to new ways to battle conditions such as muscular dystrophy, facilitate healing after surgery and benefit athletes in their efforts to recover more quickly.

“These dead cells aren’t just a nuisance, which we’ve always considered them to be,” explained UVA’s Kodi S. Ravichandran, PhD. “They have other, important roles before they leave this world.”

Important Markers
Dying cells have long been considered debris that must be removed from the body to avoid causing tissue inflammation. However, the UVA research shows that a small number of myoblasts – precursor cells that develop into muscle tissue – must die to allow muscle formation.

The finding suggests that programmed cell death, known as apoptosis, can also influence differentiation of other healthy cells within a tissue. The dying cells express a marker on their surface that signals their death and spurs the body to remove them; that same marker on these dying cells, the UVA researchers discovered, cues surrounding cells to develop into muscle fibers. The UVA researchers have identified both the membrane marker on the dying cells (a lipid normally hidden on live cells) and a corresponding receptor in the healthy myoblasts that are induced to fuse, said Ravichandran, chairman of the School of Medicine’s Department of Microbiology, Immunology and Cancer Biology.

“It’s been known for a while that there are a few muscle cells that die during exercise, and that building muscle mass depends on a few of those cells dying,” Ravichandran said. “This work puts an interesting spin on that.”

Implications for Muscular Dystrophy?
The discovery opens up many intriguing avenues for researchers to explore, including the possibility of producing muscle growth either through the direct application of apoptotic cells or by otherwise stimulating the cellular signaling pathways on the healthy cells. The genes encoding the receptor protein (called BAI1) and some of the components of the signaling pathway are found to be altered in patients with muscular dystrophy and other forms of muscle disorders.

“Because this pathway seems to be involved in muscle repair after injury, this could be relevant for recovery after surgeries, combat injuries in soldiers or any condition that could lead to muscle injury or muscle atrophy,” Ravichandran said. “Take Duchenne muscular dystrophy, for example. One in 3,500 boys that are born have this disease. If we can help alleviate the distress of even a few of these individuals, we would have made significant progress.”

Published in Nature
The findings have been published online by the prestigious journal Nature and will appear in a forthcoming print edition (along with a News and Views highlighting the impact of the work). The article was authored by Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell and Ravichandran.

 
Top Stories
a

Stable Craft Brewing Co. marks formal grand opening

Hermitage Hill Farm & Stables marked its 10th year in operation with the grand opening on Thursday of Stable Craft Brewing Co.

Spots open in ASIST suicide prevention training

Valley Community Services Board will host the Applied Suicide Intervention Skills Training (ASIST) program on Thursday/Friday May 12-13.

Augusta County grades Internet service

Augusta County is seeking help from citizens to learn about where high speed internet improvements are needed.

Shenandoah Jamboree salutes Johnny Cash

The Shenandoah Jamboree concert series returns to the Wayne Theatre with a salute to Johnny Cash on Saturday, May 7, at 7 p.m.

Waynesboro Police seek Kohl's bra, shoe thief

The Waynesboro Police Department is requesting assistance to help identify an individual involved in a theft of merchandise from Kohl's.

Local equestrian team named reserve champion at national finals

The Clover Grove Farm Interscholastic Equestrian Association Varsity Hunt Seat Team joined the top teams in the country.

Waynesboro elections: A small step forward?

I assumed the four contested races in the 2016 Waynesboro city elections would go to candidates backed by the power elite.

Waynesboro Players present The Music Man

The Waynesboro Players are opening The Music Man on Thursday night at 7:30 p.m. at Waynesboro High School.

The Doo Wop Project Live at the Wayne Theatre

The Doo Wop Project Live is coming to the Historic Wayne Theatre/Ross Performing Arts Center in downtown Waynesboro.

What if Tim Kaine ends up running for veep?

What if Tim Kaine ends up on the national Democratic Party ticket in November? This is a serious question as the primary season seems to be winding down.

 
Discussion
 
Recent News

AFP Business

AFP: The Magazine

In 2015, Augusta Free Press brought back our print magazine under a new name, Augusta Free Press: The Magazine.
.
 

Advertise on AFP

Get information on AFP readership and advertising online with us.
.
 

AFP Classes

Augusta Free Press offers a series classes on website design, marketing strategy, social media, event planning and more.
.
 

AFP Web Design

Get your business online for as little as $1,299. We take care of all facets of web design – visual design, layout design and content development.
.
 

AFP Graphic Design

Whether you need a fresh business card design, rack card, ad, flyer or full magazine design, we can help with all your graphic-design needs.
.

AFP Marketing/PR

Augusta Free Press manages advertising campaigns for small- and medium-sized businesses across Virginia. You don’t need to hire a full-time marketing coordinator. Bring the experience of the Augusta Free Press team to work for you – for a fraction of the cost.
.
 

AFP Search Engine Optimization

The prettiest website in the world is like a tree falling in the forest with no one there to hear it. If your website hasn’t been search engine optimized, no one is going to see it or hear it – and it’s not going to work for you.

 

AFP Video/Audio

Web videos, TV and radio commercials, DVDs – Augusta Free Press LLC has you covered when it comes to video and audio production.
.
 

AFP Book Publishing

Augusta Free Press Publishing has produced books in-house and assisted more than 17 authors with book publishing and production services since 2003. Whether you need a cover, layout, or need help from start to finish, we are here to help!
.