
The Spiders (19-6, 9-3 A-10) shot 7-of-12 from three in the first half to go into the locker room up 42-24.
VCU (17-8, 7-5 A-10) would briefly get the margin to 13, but a 12-2 UR run punctuated by a steal and breakaway layup by Jacob Gilyard pushed the margin to 54-31 with 14:53 remaining.
The Rams never recovered.
Marcus Santos-Silva provided 14 points, 12 rebounds, three steals and two assists to the VCU cause. He finished 6-of-11 from the floor and 2-of-3 at the free throw line.
Nick Sherod led five Spiders in double figures with a game-high 23 points. He hit 5-of-7 from 3-point range.