Sterling Shepard tore his left ACL in the New York Giants’ 23-16 loss to the Dallas Cowboys on Monday Night Football.
Shepard, the team’s leading receiver through three games, was injured on the final offensive snap for the Giants.
The non-contact injury occurred while Shepard was jogging near the right sideline.
Shepard has 13 catches on 24 targets for a team-high 157 yards in 2022.
The 2016 second-round pick has only played a full season two times in his seven-year career, missing a total of 25 games to Achilles, quad, hamstring, toe and concussion injuries.
The Giants (2-1) host the Chicago Bears (2-1) on Sunday.