UVA alum Tyler Wilson had a quality start for the Orioles, but a Luis Valbuena solo homer was the difference in a 4-3 Houston win.
Wilson (2-3, 3.80 ERA) gave up four runs, three earned, in six innings, allowing six hits and striking out four.
Jonathan Schoop staked Baltimore (26-18) to an early 2-0 lead in the first with a two-run double, but that would be it for the offense for the night.
The O’s trailed 3-2 in the sixth when Chris Davis scored on a wild pitch, but the Valbuena homer broke the 3-3 tie.
Baltimore would get baserunners on in each of the last three innings, including Davis on a one-out double in the ninth, but the Orioles could not come through in the clutch.