Virginia State Police responded to a single-vehicle crash in Albemarle County at 8:52 a.m. Sunday.
A vehicle traveling on Interstate 64 ran off the left side of the highway near the 117 mile marker and overturned in the median.
The driver was ejected from the vehicle and died at the scene.
The passenger was transported to UVA Medical Center for treatment of serious injuries.
The crash remains under investigation.